The CD8 T cell response to vaccinia virus exhibits site-dependent heterogeneity of functional responses
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The CD8 T cell response to vaccinia virus exhibits site-dependent heterogeneity of functional responses.
CD8 T cell responses to vaccinia virus (VV) and a virus-encoded ovalbumin peptide (OVAP) epitope were examined using adoptively transferred OT-I T cells. The results demonstrate that upon intra-peritoneal challenge with ovalbumin-expressing VV (VV-OVAP), OT-I T cell proliferation occurs initially in lymph nodes and spleens followed by migration of the divided cells to the peritoneal cavity. Mas...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2007
ISSN: 0953-8178,1460-2377
DOI: 10.1093/intimm/dxm039